Suspect SM Systemic Mastocytosis
For US healthcare professionals only
Symptoms of systemic mastocytosis (SM) may be mistaken as other disorders and conditions, leading to diagnostic delays1,2
It is important to recognize the symptoms of SM to help reduce the time to diagnosis and treatment
Historically, it has taken ~6 years for patients living with SM to receive a diagnosis and often involves a diverse group of specialists.1,3 Symptoms of SM include skin lesions, diarrhea, and anaphylaxis, and can be perceived as a variety of related disorders.2,4
Expand to see how these disorders are different from SM
Adult-onset mastocytosis in the skin (MIS)/cutaneous mastocytosis (CM)
~90% of patients presenting with adult-onset mastocytosis in the skin may have SM5,6
Various skin lesion presentations associated with SM5
Skin lesions typical of mastocytosis can exhibit swelling, reddening, or pruritus, which can occur when mast cells are activated, such as by stroking skin lesions (Darier’s sign) or changes in temperature.4,7,8
In adult patients with SM who have skin lesions, the lesions are typically monomorphic maculopapular lesions (known as MPCM or UP) and present as small, round, and pigmented.7 The number of lesions may vary among patients, ranging from a few to possibly widespread coverage.7
Other subvariants include DCM and mastocytoma.7,9
Not an actual patient.
Review a hypothetical case study of a patient presenting with skin lesions ultimately diagnosed with SM.
- DCM=diffuse cutaneous mastocytosis; MPCM=maculopapular cutaneous mastocytosis; UP=urticaria pigmentosa.