64%
of patients experience diarrhea4*
Whereas increased presence of gastrointestinal (GI) mucosal mast cells is seen in many common GI disorders, spindle-shaped mast cell aggregates and/or CD25 expression are unique to SM.5
Suspect SM Systemic Mastocytosis
For US healthcare professionals only
Unpredictable and potentially severe symptoms can occur in patients with systemic mastocytosis (SM)1-3
Recognizing the symptoms of SM may help with earlier identification
In SM, skin lesions, diarrhea, anaphylaxis, and other symptoms often appear with unexplained persistence or recurrence.1,2
Select each of the cards below to learn about these common symptoms of SM
95%
of patients have
maculopapular skin lesions6†
Small monomorphic lesions often appear on the thighs or trunk of the body.6
Wheal-and-flare reaction is elicited by stroking lesion with tongue spatula (Darier's sign).6
50%
of patients experience
anaphylaxis6†
Commonly triggered by hymenoptera stings (such as bees or wasps) or can be idiopathic.3
Anaphylaxis is often coupled with hypotension and can be life-threatening.3
- *Data from a validation study of 2 patient-reported outcome measures of quality of life and symptom burden in 164 patients with indolent systemic mastocytosis (ISM).4
- †As described by an expert-panel review of adult-onset mastocytosis (predominantly indolent population).6
Other common symptoms include brain fog, headache, dizziness, abdominal pain, nausea, itching, flushing, bone pain, and fatigue. These are not all the possible symptoms patients with SM may experience.1,2
Are your patients exhibiting symptoms of SM?
Consider initiating testing for serum tryptase and KIT D816V at the first sign of the disease.2,7
LEARN MORE“I am filled with fear about eating. I am filled with fear about going to sleep. I am filled with fear about being alone.”
Kristine, a patient describing the unpredictability of ISM symptom triggers
SYSTEMIC1
- Fatigue
- Weight loss
- Anaphylaxis with
hypotension - Malaise
RESPIRATORY2
- Dyspnea
- Nasal congestion
- Throat swelling
- Wheezing
MUSCULOSKELETAL1
- Bone pain
- Myalgia
- Osteoporosis,
osteopenia, and osteolytic
lesions
SKIN2
- Pruritus
- Flushing
- Maculopapular lesions
CARDIOVASCULAR1
- Hypotension
- Dizziness
- Palpitations
NEUROPSYCHIATRIC2
- Memory impairment
- Brain fog
- Anxiety
- Migraines
GASTROINTESTINAL1
- Nausea/vomiting
- Diarrhea
- Abdominal pain
- Heartburn or reflux
Not an exhaustive list of all symptoms.
Symptoms may vary from person to person.
Woman-with-head-in-hands
Did you know? Symptoms of SM can be perceived as various other disorders and conditions, leading to diagnostic delays2,8
This includes adult-onset mastocytosis in skin/cutaneous mastocytosis (MIS/CM), irritable bowel syndrome (IBS), and nonclonal mast cell activation syndrome (nc-MCAS).2,9,10
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